Non-invasive diagnostics for liver diseases of different origins and highly sensitive laboratory parameters for intrahepatic cholestasis during pregnancy.
Important functions of the bile acids are the excretion of cholesterol via the intestine, intake of fats and fat-soluble vitamins in the small intestine as well as stimulation of intestinal motility.
Bile acids are the final products of the cholesterol metabolism of the liver and, together with the other components of the bile, e. g. cholesterol, bilirubin, phospholipids and proteins, are secreted into the duodenum.
Most of the bile acids secreted daily are reabsorbed in the terminal ileum, introduced via the portal vein to the liver, and excreted again with the bile. This process, which is also called enterohepatic circuit, leads to the fact that only 3 - 5% of the bile acids are excreted with the stool every day.
Disorders of bile acid metabolism may occur at various sites of the enterohepatic circuit, e. g. disturbed bile acid synthesis or transport (intrahepatic cholestasis or extrahepatic occlusion of the bile ducts), disturbed bile acid absorption in the intestine or impaired reabsorption in the liver.
Congenital (metabolic diseases) or acquired liver diseases (caused by medicines, toxins and infections) can also interfere with bile acid metabolism and thus cause measurable changes in bile acid concentration in the blood. Thus, bile acids in the blood are a sensitive biomarker for liver diseases.
The intrahepatic cholestasis in pregnancy (ICS) is triggered by increased hormone levels during late pregnancy. In most cases a genetic predisposition is present in the patient. Since untreated ICS is associated with the risk of premature birth, complications in the newborn or intrauterine death, specific diagnosis and therapy are essential.
The IDK® Bile Acids Test measures photometrically all free bile acids in serum and serves the diagnosis of liver diseases. No additional laboratory equipment is required for HPLC or LC-MS.
microtiter plate test K 7877W
cuvette test K 7877CV