Glutathione peroxidase (GPx) is one of the most important enzymes for detoxification of peroxides in living cells. GPx plays a crucial role in protecting cells from damage by free radicals which are formed by peroxide decomposition. Lipid components of the cell are especially susceptible to reactions with free radicals resulting in lipid peroxidation. GPx reduces peroxides to alcohols using glutathione thus preventing the formation of
free radicals.
Cellular GPx is present in all tissues; however, various diseases may influence its level. An increase in the level of glutathione peroxidase has been observed in reticulocytes of diabetic rats. The level returned to normal after administration of insulin. A decrease in the level of the enzyme has been observed in patients suffering from diseases such as hairy cell leukemia or Favism (a disease associated with extreme hemolytic crisis).
Indication
- Detoxification marker
