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Zonulin (IDK® Zonulin) (Stool) ELISA
K5600, 5600
Article number:
K 5600
Tests:
96 Tests
Incubation time:
1 h; 1 h;10-20 min
Volume:
15 mg
Matrix:
Stool
Standards:
0.25 - 16 ng/ml
Method:
ELISA
Details (PDF)
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Zonulin is a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which participates in tight junctions between cells of the wall of the digestive tract. Zonulin binds to a specific receptor on the surface of intestinal epithelia and triggers a cascade of biochemical events which induces tight junction disassembly and a subsequent permeability increase of the intestinal epithelia, allowing some substances to pass through and activate immune reactions.
A. Fasano and his co-workers found out that the zonulin zonulin-receptor system is more activated in celiac disease and type 1 diabetes mellitus patients. Patients with active celiac disease showed higher levels of zonulin and anti-zonulin antibodies compared to non-celiac patients and patients in remission, who were eating a gluten-free diet.
Concerning the autoimmune type 1 diabetes, in experiments with rats could be demonstrated, that elevated zonulin levels as well as increased intestinal permeability precede a type 1 diabetes disease. Conversely, type 1 diabetes could be prevented by inhibition of zonulin in animal experiments.
In addition, it was reported that many people who suffer from celiac disease also suffer from other autoimmune disorders. It is suggested that increased levels of zonulin are a contributing factor to the development of celiac disease and other autoimmune disorders such as insulin dependent diabetes, multiple sclerosis, and rheumatoid arthritis.

An ELISA for the detection of Zonulin for research purposes is now available.

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