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ox-LDL/MDA Adduct ELISA
K7810, 7810
Article number:
K 7810
Tests:
96 Tests
Incubation time:
1h; 1h; 10-20min
Volume:
10 µl
Matrix:
EDTA-Plasma, Serum
Standards:
9 - 250 ng/ml
Method:
ELISA
Details (PDF)
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Lipid peroxidation is a natural process essential for cell growth. However, when the oxidative stress overwhelms the antioxidative cell defense, the balance is disturbed and enhanced formation of lipid peroxidation products occurs. At present, lipid peroxidation is considered to be one of the basic mechanisms involved in the initiation and progression of many diseases. Various studies have provided evidence that oxidative stress resulting in lipid peroxidation and protein modification is involved in the pathogenesis of atherosclerosis and coronary heart disease.
Lipid peroxidation products are formed during normal cell metabolism via producing an excess of free radicals that can react with unsaturated fatty acids, in particularly low-density lipoprotein (LDL), the major carrier of plasma cholesterol. LDL is eliminated by macrophages. Normally, receptor-mediated uptake of LDL is suppressed through down-regulation of LDL receptor expression in response to increasing cholesterol levels. Once LDL is oxidized, it is still internalized by macrophages but through scavenger receptors whose expression is not controlled by cholesterol loading. The binding of oxidized LDL (oxLDL) is the step by which cholesterol accumulation in macrophages is induced transforming them into lipid-loaded ‘foam cells’. This process is accompanied by extensive cell proliferation and elaboration of extracellular matrix components and contributes to the genesis and progression of atherosclerosis by promoting endothelial damage and amplifying the inflammatory response within the vessel wall. Cholesterol-loaded macrophage ‘foam cells’ are present in the earliest detectable atherosclerotic lesions, the precursor of more complex atherosclerosis that cause stenosis and limited blood flow. These advanced lesions ultimately represent the sites of thrombosis leading to myocardial infarction.
Our oxLDL ELISA Kit is intended for the quantitative determination of oxLDL in EDTA-plasma and serum.


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