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Thymosin ß4 ELISA
Article number:
KR9520
Tests:
96
Incubation time:
1 h, 1 h, 10-20 min
Volume:
50 µl
Matrix:
Serum, Thymus extract
Standards:
0.16-10 µg/ml
Method:
ELISA
Details (PDF)
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For research use only.
The beta-thymosins are a family of highly conserved polar 5 kDa peptides originally thought to be thymic hormones. Further studies demonstrated that the molecule is ubiquitous; it had been found in a variety of tissues and cell lines. It is found in highest concentrations in spleen, thymus, lung, and peritoneal macrophages. Thymosin beta 4 binds monomeric actin in a 1:1 complex and act as actin buffers, preventing polymerization into actin filaments but supplying a pool of actin monomers when the cell needs filaments. Changes in the expression of thymosin beta 4 appear to be related to the differentiation of cells. Thymosin beta 4 is detected outside of cells in blood plasma or in wound fluid. Several biological effects are attributed to thymosin beta 4, like induction of metallo-proteinases, chemotaxis, angiogenesis and inhibition of inflammation as well as the inhibition of bone marrow stem cell proliferation.

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