anti-human tissue transglutaminase sIgA (anti-htTG sIgA), ELISA
1h, 1h, 15min
In most celiac patients, one usually observes several disorders, like malabsorption, infertility, osteoporosis and delayed growth of children. But it has also been widely reported that celiac disease is associated with a whole series of autoimmune disease, e.g. Dermatitis herpetiformis Duhring, Diabetes mellitus, rheumatoid Arthritis, IgA-nephritis, neuro-psychiatric disorders, Hashimoto-Thyreoditis/M. Basedow and an increased risk of developing malignant T cell lymphoma. Dieterich et al. have shown, that tissue transglutaminase (tTG) is the predominant, if not the sole, endomysial autoantigen characteristic for celiac disease.Because the prevalence of associated autoimmune disease in most cases is high, it is advisable to look for autoantibodies against tissue transglutaminase (tTG) as marker for those autoimmune disease. The anti-Transglutaminase sIgA ELISA is suitable for the determination of sIgA antibodies from faeces, which is of special clinical interest in paediatrics as mainly little children are affected, whereas the anti-Transglutaminase IgA detects IgA from serum.