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Vitamin K1 (Phylloquinone) HPLC
KC 2400, K C2400, K C 2400
Article number:
KC2400
Detection Elution:
Fluorescence
Tests:
100 Tests
Volume:
1 ml
Matrix:
Plasma, Serum
Standards:
isocratic
Method:
HPLC, Fluorescence
Details (PDF)
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Vitamin K1 is a derivative of 2-methyl-1, 4-naphtoquinone and is found in green plants. Vitamin K1 is insoluble in water and readily soluble in ether, n-hexane and chloroform.
It`s an essential co-factor in the posttranslational carboxylation reaction of glutamic acid residues (GLU) to g-carboxyglutamic acid residues (GLA) in a number of blood clotting factors and also in some other proteins e.g. osteocalcin. The adjacent carboxyl groups of the GLA-residues provide the Vitamin K dependent proteins with characteristic calcium- and phospholipid-binding properties that are essential for their activation and function.
A decrease in Vitamin K1 is reported in osteoporotic patients. Other clinical symptoms of Vitamin K1 deficiency are clotting disorders, which manifest themselves as bleeding in the skin, in the mucous membranes, in muscles and in internal organs. Symptoms of deficiencies normally appear within few days.
Vitamin K1 is rapidly metabolised and only minor amounts are stored in the organism.

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