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MutaGEL® Laktase (AS), PCR
KE 09009, K E09009, K E 09009
Article number:
24 Tests
200 µl
DNA (e. g.whole blood, cheek swab)
PCR (allel specific)
For research use only.

Patients with lactose intolerance are not able to digest milk-sugar taken in with food. Due to this fact, afflicted persons suffer subsequently under malabsorption problems like nausea, flatulence, diarrhoea or stomach pain. Most important reason for lactose intolerance is founded in a genetically caused
lack of digestion enzyme lactase which is responsible for degradation of milk-sugar in the organism. This common gene defect occurs by T/C base replacement at position -13910 in a regulatory region of LCT gene for the enzyme lactase-phlorizin hydrolase (LPH). In case of homozygous present C-allel,
lactase-deficiency and subsequently lactose malabsorption (primary lactose intolerance) is predetermined. Manifestation of lactose intolerance occurs mostly after childhood. In Europe, the prevalence of this homozygous C/C-genotype is about 10 - 20 % (in South European countries even more, up to 50 %).
Therefore, alone in Germany about 15 million people are afflicted from malabsorption problems due to lactose in milk products. MutaGEL® Laktase allow the analysis of this T/C-replacement at position -13910 in regulatory region of lactase gene (LCT) responsible for reduced lactase activity

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