PMN-Elastase (IDK® PMN-Elastase) (Stool) ELISA
3 x 1 h; 10-20 min
PMN-Elastase from human polymorphnuclear granulocytes is a glycoprotein of 30 kDa and belongs to the group of serine proteases. Active PMN-Elastase is released from azurophil granula of neutrophil granulocytes after irritation or disintegration. The determination of the PMN-Elastase in stool is used to record inflammatory reactions where neutrophils are involved. Especially in CrohnÂ´s disease the inflammatory process go hand in hand with an increased phagocytic activity and the biological decay of these cells and thus leads to an increased release of PMN-Elastase and other lysosomal enzymes.