Immundiagnostik's Colorectal Cancer Screening Portfolio

IDK Portfolio for Colorectal Cancer Screening


Regular participation in colorectal cancer (CRC) screening programmes can reduce the number of colorectal cancer cases as well as mortality rates (Brenner et al., 2014; Zorzi et al., 2015)*. Quantitative Fecal Immunochemical Tests (FIT) are recommended for colorectal cancer population screenings. An advantage of quantitative tests is the ability to vary cut-off values, which allows an adaption to current conditions, such as national colonoscopy resources, gender and age-specific differences. In addition, this makes it possible to react quickly to new findings regarding the cut-off (e.g. adjustment during an ongoing screening procedure) (Zorzi et al., 2015., Segnan N et al., 2010).
Immundiagnostik AG offers a comprehensive immunological colorectal cancer screening portfolio for low and high sample throughputs.

Reliable colorectal cancer screening with IDK® Hemoglobin ELISA (K 7816D)
IDK® Hemoglobin ELISA is a quantitative sandwich ELISA for the detection of human haemoglobin. Gies et al. (2019) described the IDK® Hemoglobin ELISA as the FIT test with the best diagnostic performance, whose significance could not be improved by combining it with other iFOBTs (Gies et al., 2019).

Free haemoglobin is bound by haptoglobin, a blood protein. The haemoglobin-haptoglobin complex is more stable during intestinal transit than unbound haemoglobin and therefore also indicates bleeding adenomas and carcinomas of the upper intestinal tract. The combination of IDK® Hemoglobin ELISA and IDK® Hemoglobin-Haptoglobin complex ELISA (K 7817D) achieves the highest sensitivity with regard to the early detection of colorectal cancer (Sieg et al., 1999; Lüthgens et al., 1998).

IDK® Hemoglobin ELISA and IDK® Hemoglobin-Haptoglobin complex ELISA can be used with IDK Extract® (K 6999):

  • an easy and hygienic stool sample preparation system that is suitable for sample collection, storage and preparation
  • no sample weighing is required for the sample collection
  • the IDK Extract® extraction buffer contained in the stool sample tube allows the stool sample extract to be stored for 7 days at -20°C, 2-8°C and room temperature
  • the system is ready-to-use and can be used directly for manual as well as for automated processing

High-throughput colorectal cancer screening? No problem with IDK® TurbiFIT® (TU1031)!
IDK® TurbiFIT® is a particle-enhanced turbidimetric immunoassay (PETIA) - which correlates excellently with the IDK® Hemoglobin ELISA and is compatible with any open clinical chemistry analysis system. Continuous loading and a random-access workflow in combination with a low hands-on time allow a high sample throughput while reducing costs. For sample collection, storage and processing, IDK® TurbiTUBE® (TU0091.A) is ideally suited. The system is ready-to-use, so the tubes can be placed directly in the analyser.

¹ Brenner H, Stock C, Hoffmeister M. Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ. 2014 Apr 9;348:g2467. doi: 10.1136/bmj.g2467. PMID: 24922745; PMCID: PMC3980789.
² Zorzi M, Fedeli U, Schievano E, Bovo E, Guzzinati S, Baracco S, Fedato C, Saugo M, Dei Tos AP. Impact on colorectal cancer mortality of screening programmes based on the faecal immunochemical test. Gut. 2015 May;64(5):784-90. doi: 10.1136/gutjnl-2014-307508. Epub 2014 Sep 1. PMID: 25179811.
³ Segnan N, Patnick J, von Karsa L (eds); European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis - First Edition; 2010
⁴ Gies A, Cuk K, Schrotz-King P, Brenner H. Combination of Different Fecal Immunochemical Tests in Colorectal Cancer Screening: Any Gain in Diagnostic Performance? Cancers (Basel). 2019 Jan 20;11(1):120. doi: 10.3390/cancers11010120. PMID: 30669538; PMCID: PMC6356298.
⁵ Sieg A, Thoms C, Lüthgens K, John MR, Schmidt-Gayk H. Detection of colorectal neoplasms by the highly sensitive hemoglobin-haptoglobin complex in feces. Int J Colorectal Dis. 1999 Dec;14(6):267-71. doi: 10.1007/s003840050226. PMID: 10663892.
⁶ Lüthgens K, Maier A, Kampert I, Sieg A, Schmidt-Gayk H. Hemoglobin-Haptoglobin-Complex: A Highly Sensitive Assay for the Detection of Fecal Occult Blood. Clin. Lab. 1998;44(7-8):543-551

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