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Test-Category
ELISA
Pack size
96 Tests
Standard concentrations included in the kit
0-80 U/ml
Possible sample matrix and volumes
| Serum | 10 µl |
INTENDED USE
Anti-Integrin αvβ6 ELISA is a non-automated in vitro diagnostic test intended for use by healthcare professionals in a laboratory setting for the quantitative determination of anti-integrin αvβ6 antibodies in human serum using ELISA (Enzyme-Linked Immunosorbent Assay). The determination of anti-integrin αvβ6 antibodies serves as an aid in the diagnosis of ulcerative colitis (UC).
SUMMARY AND EXPLANATION
Integrins are heterodimeric cell surface receptors involved in cell-matrix and cell-cell adhesion. Furthermore, integrins mediate bidirectional signaling between cells and their environment and are involved in the regulation of a variety of cellular processes, including cell proliferation, migration, survival, tissue invasion, and innate immunity. Mammalian cells possess 18 different integrin α subunits and 8 β subunits, which can combine in various ways to form 24 different receptor heterodimers. Integrin αvβ6 is expressed exclusively by epithelial cells, including in the intestinal epithelium, where it functions as a receptor for extracellular matrix proteins such as fibronectin and is involved in suppressing inflammation as well as preventing infections by pathogens and parasites [1]. Anti-integrin αvβ6 antibodies have been detected in the vast majority of patients with ulcerative colitis, and it has been reported that antibody titers correlate with disease activity [2].
REFERENCES
[1] Koivisto L, Bi J, Häkkinen L, Larjava H. Integrin αvβ6: Structure, function and role in health and disease. Int J Biochem Cell Biol. 2018;99:186-96.
[2] Kuwada T, Shiokawa M, Kodama Y, Ota S, Kakiuchi N, Nannya Y, et al. Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis. Gastroenterology. 2021;160(7):2383-94.e21
