Thiol-Status (Sulfhydryl-Status Test), photometric

Article number: K 1800

Test-Category

Miscellaneous

Test-Method

photometric

Pack size

96 Tests

Standard concentrations included in the kit

one point calibration

Possible sample matrix and volumes

Serum 20 µl
Plasma 20 µl
Urine 20 µl
Synovia 20 µl

Incubation periods

  1. 30 minutes

Indications

Regulatory Status

CE marked

Serum protein thiol levels in blood are a direct measure of the in vivo reduction/oxidation (redox) status in humans, because thiols react readily with oxygen-containing free radicals to form disulfides. Moreover, serum thiols also reflect DNA repair capacity and the possible eventual accumulation of genetic damage, since a key DNA repair enzyme, poly ADP-ribose polymerase (PARP), is thiol/disulfide redox regulated.
Serum protein thiols can possibly be used to estimate individual aging status. Data from Banne AF et al. (2003, Anti Aging Med 6:327-34) strongly confirm an important role of oxidative stress in human disease development, and identify serum thiol status as a potential biochemical endpoint useful in the assessment of aging.