Elevated urine kryptopyrrole might result in Vitamin B6 and zinc deficiency symptoms
Kryptopyrroluria involved in behavior and emotional disorders
Kryptopyrrole appears in the urine of patients undergoing severe physiological or psychological stress. The 2,4 dimethyl-3-ethylpyrrole is a byproduct of hemoglobin synthesis. The presence of urinary kryptopyrrole (mauve factor) was first reported in patients with LSD psychosis. High levels were also found in the urine of schizophrenic patients. It has been found out that circulating kryptopyrrole forms a Shiff base with the aldehyde form of vitamin B6 (pyridoxal 5 phosphate) in the blood. This combination then binds with zinc and builds an unsoluble complex. As large amounts of kryptopyrroles are excreted in the urine, it depletes the blood of vitamin B6 and zinc. The reason for increased kryptopyrrol synthesis might be an inborn error of the pyrrole chemistry or a disorder incuced by environmental conditions or stress.
Urine specimen collection and transport is very important for proper test results. Special urine test tubes for the determination of kryptopyrrole can be ordered in addition to the test kit.
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