Mutations in the SARS-CoV-2 spike protein gene

Update: IDK® SARS-CoV-2 PCRs are not influenced by new virus variants

07.06.2022

Immundiagnostik's respiratroy PCR assays MutaPLEX® Coronavirus (KG1926), MutaPLEX® RespiraScreen 1 (KG1927), MutaPLEX® RespiraScreen 2 DIFF (KG1928) and MutaPLEX® Coronavirus 4G (KG1936) were screened for the spike protein mutations in the following viral variants:

  • [Omicron] (BA.1, BA.2, BA.4, BA.5)
  • [Omicron] (BA.3, BA.2 + L452X)
  • [Alpha], [Beta], [Gamma], [Delta] (all AY Subvariants)
  • [Epsilon], [Zeta], [Eta], [Theta], [Iota], [Kappa], [Lambda], [Mu]

None of the spike protein mutations in the listed viral variants (see Update*) showed any effect on the diagnostic sensitivity and specificity of the above mentioned real-time RT-PCRs.

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